Nusrat Sharmin
University of Nottingham Ningbo, china
Title: Phosphate Based Glasses for Biomedical Applications: Effect of Composition
Biography
Biography: Nusrat Sharmin
Abstract
For the last few decades, there has been a growing interest in using glasses for biomedical applications. Phosphate based glasses (PBGs) are known to show good bioactive characteristics and could be potentially used as favourable templates for bone-tissue formation. Phosphate glasses are unique group of materials that offer great potential for hard and soft tissue engineering over other types of bioactive glasses due to their fully resorbable characteristics, with some formulations possessing chemical composition similar to the mineral phase of natural bone. The biocompatibility of these glasses is hugely affected by the glass composition which could be easily altered via the addition of different modifying oxided. The main aim of this current work was to establish a relationship between the ion release and cytocompatibility of PBGs. Different modified oxides (Fe2O3, B2O3, SrO) were added to the glasses in order to observe the effect of composition on the durability of the glasses. Ion release studies were conducted using inductively coupled plasma spectroscopic method. In order to observe the relationship between the ion release, degradation rate and cytocompatibility of the glasses cell culture studies were conducted using human osteoblast like (MG63) cell lines. It was revealed that the glasses containing both B2O3 and Fe2O3 maintained and showed higher cell viability as compared to the only Fe2O3 or B2O3 or SrO containing glasses. This positive effect of glass composition on the cytocomapatibility properties of PBGs was mainly associated with the degradation rate and corresponding ion release.